[darbikrash]

I’ll throw out some thoughts, not meant as gospel, just a perspective.

I think it depends on the type of forced induction. For a turbo car, I’d think the higher compression/lower boost approach would work better on E85 - the idea being the higher compression will net an engine that is more responsive when it is off boost, with less turbo lag as well.

With a blower - as opposed to a turbo, again I think it depends on what type of blower. A centrifugal builds boost slower and the boost comes on at a higher rpm than a twin screw, so for the centrifugal the higher compression approach might also make more sense.

For the twin screw, these blowers typically throw all the boost in right away, and the engine is under boost almost at any rpm off idle, so the engine will be responsive in virtually all circumstances. In this case I think the lower compression approach might be the best solution.