My experience has been with my 1966 Grand Prix and a 1966 Parisienne. The Parisienne is essentially a Catalina body on a Chev chassis. While there are substantial differences in the sheet metal, core support and bumpers in the way they are hung, I fully believe (if I had wanted to), I could have bolted the grill sections from either car into the other car.
In other words, I'm saying I have no reason to doubt you could put a Grand Prix front into your 2+2. Just can't see any reason why the core supports will be different.
Let us know what you decide to do.
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To laugh at men of sense is the privilege of fools.
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