Just a thought if you suspect pickup wires are the cause. Assuming you are using vacuum advance, when you stab the throttle, you're loosing vacuum, causing the vacuum can to pull timing out flexing those pickup wires. Maybe disconnect the vacuum can and take it for a drive and see if the problem still exists.
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'78 Macho T/A DKM#95, 460cid, SRP pistons, KRE 310 D ports,
3" pypes, Hooker 1 3/4" headers, hydraulic roller,
10" Continental, 3.42 gears
11.5 @117.5mph 3900lbs 
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