Sure! they can run very well. For more specific info on the Buick 350 check this link...
http://www.v8buick.com/forumdisplay.php?s=&forumid=8
You have some decent options for that engine. It's a very tough engine and is designed well.
Deep skirt block
Long rods
Long stroke
Modern combustion chambers
Sparkplug bias to the exhaust side
Distributor in front
Lighter than a small block Chevy!