[Will]

I'm no expert but I'd think that XE262 would probably work decently in a medium compression 350 with a mild stall (or manual) and mid 3-series gearing behind it. Good flowing exhaust will really help.

I ran a Comp 270 Magnum with Crane Hi-Intensity lifters (similar to Rhoads but slightly less effective at improving low speed characteristics by all accounts) in an 8.5:1 400 with stock log manifolds backed up by an M-20 and 3.73 gears. It was a bit soft on the bottom end but came on strong at 2500 and pulled well to 5000 where it ran into a wall. The XE 262 should produce similar results in a 350, maybe even be a bit better on the bottom end. That 400 would likely have pulled better on the top end with headers and something better than a 2" compression bent exhaust system.

The tighter the lobe separation the more the engine needs good flowing exhaust to make upper RPM power, in general.