Just about every reputable builder Ive spoken to about cast cranks across multiple engine families says that the cast cranks are stronger than given credit for. Same with two bolt main setups. I wouldn't hesitate with a cast crank well north of 400 HP. I wouldn't give up the cubic inches with your goals.
With the parts you have listed you are going to easily be 400+.
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1967 Firebird 462 580hp/590ftlbs
1962 Pontiac Catalina Safari Swapped in Turd of an Olds 455
Owner/Creator Catfish Motorsports
https://www.youtube.com/@CatfishMotorsports
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